Does Creatine Increase Appetite? The Science Behind Hunger, Muscle Growth, and Weight Loss
Creatine monohydrate has earned its reputation as one of the most effective and well-researched sports supplements available. It's commonly used to improve strength, increase lean muscle mass, enhance high-intensity exercise performance, and support recovery.
But after a few weeks of taking creatine, many people notice something unexpected.
They begin asking, "Does creatine increase appetite?" Maybe you've started eating more. Maybe you're hungrier after workouts. Or maybe you're trying to lose weight and you're worried that creatine will make sticking to your nutrition plan more difficult.
The good news is that current scientific evidence does not show that creatine monohydrate directly increases appetite in healthy individuals.
However, that doesn't mean you can't feel hungrier after starting creatine.
The difference is important. In many cases, people who begin taking creatine also begin:
Training harder
Lifting heavier
Recovering better
Exercising more consistently
Building more lean muscle
Those changes naturally increase your body's energy demands. In other words, it may not be the creatine making you hungry. It may be the improvements in your training that are increasing your body's need for energy.
As a Human Performance expert, I've found this is one of the most misunderstood aspects of sports nutrition. People often blame a supplement when the real explanation is that they're finally doing enough work to require additional fuel.
That's actually a good problem to have.
Understanding why you're hungry, and whether it's true physiological hunger or simply habit, stress, or cravings, can help you make better nutrition decisions without unnecessarily eliminating one of the most researched supplements available.
In this guide, you'll learn:
Does creatine increase appetite?
Does creatine make you hungry?
Can creatine increase cravings?
Does creatine affect hunger hormones?
Can creatine make weight loss harder?
Why might you feel hungrier after starting creatine?
Should you stop taking creatine while dieting?
How creatine fits into a sustainable Human Performance nutrition strategy
Let's separate what the research actually says from what social media often assumes.
Quick Answer
Does Creatine Increase Appetite?
Current research does not demonstrate that creatine monohydrate directly increases appetite or hunger in healthy adults.
Creatine's primary role is to increase phosphocreatine stores within skeletal muscle, allowing faster regeneration of ATP during repeated high-intensity exercise. Appetite regulation, on the other hand, is influenced by a complex interaction of hormones, energy expenditure, sleep, stress, food intake, and activity levels.
What many people experience is an indirect increase in hunger because creatine often helps them:
Train harder
Increase workout volume
Improve recovery
Build lean muscle
Become more physically active
When your body expends more energy, it is completely normal for hunger to increase. That doesn't necessarily mean the creatine itself is stimulating your appetite. The International Society of Sports Nutrition (ISSN) continues to recognize creatine as one of the safest and most effective supplements for improving exercise performance, but increased appetite is not considered one of its established physiological effects.
🎯 Wondering If You're Actually Hungry or Just Undereating?
If you're trying to lose body fat while taking creatine, understanding your daily calorie and protein needs is far more important than worrying about whether creatine affects appetite.
Use the FREE Human Performance HQ Macro Calculator below to calculate your personalized:
Daily calorie target
Protein intake
Carbohydrate intake
Fat intake
Weight-loss calorie goal
👉 Get The FREE Human Performance HQ Macro Calculator.
Knowing how much your body actually needs often explains changes in hunger much better than blaming one supplement.
How Is Appetite Actually Regulated?
To answer whether creatine increases appetite, we first need to understand what controls hunger. Most people think appetite is controlled by one hormone. In reality, it's regulated by dozens of physiological systems working together.
Some of the biggest influences include:
Energy expenditure
Sleep quality
Protein intake
Meal timing
Stress
Hydration
Physical activity
Hormones
Food environment
Psychological factors
This complexity is one reason nutrition science rarely produces simple yes-or-no answers. Appetite isn't controlled by one supplement. It's controlled by your entire physiology.
Ghrelin: The Hunger Hormone
One of the primary hormones involved in appetite regulation is ghrelin.
Ghrelin is often called the "hunger hormone" because it:
Increases before meals
Stimulates appetite
Encourages food intake
Helps regulate energy balance
When you've gone several hours without eating, or after prolonged calorie restriction, ghrelin levels typically rise. That increase has nothing to do with creatine itself. It's your body's natural response to needing energy.
Leptin: The Satiety Hormone
Leptin works almost opposite to ghrelin. Produced primarily by fat tissue, leptin helps signal that you've eaten enough. When energy stores decline over time, such as during prolonged dieting, leptin levels often decrease.
This reduction can increase hunger while making weight loss feel more difficult.
Again, this is driven largely by: Body fat, energy balance, calorie restriction not creatine supplementation.
Does Creatine Affect Hunger Hormones?
This is one of the most common questions I receive. Current evidence does not clearly demonstrate that creatine directly alters ghrelin, leptin, or other major appetite-regulating hormones in healthy adults.
Researchers have extensively studied creatine's effects on:
Muscle performance
ATP regeneration
Strength
Recovery
Brain function
Neuromuscular performance
However, increasing appetite has not emerged as one of creatine's established physiological mechanisms. That distinction is important. Just because someone notices increased hunger after beginning creatine doesn't mean creatine directly caused it. Correlation doesn't automatically equal causation.
Why Might You Feel Hungrier After Starting Creatine?
This is where the story becomes more interesting. Although creatine probably isn't directly increasing appetite, it may indirectly contribute to greater hunger through improvements in training. Consider what often happens after several weeks of consistent creatine supplementation.
Many people report:
More productive workouts
Increased strength
Better recovery
More repetitions
More training volume
Increased confidence in the gym
Those improvements increase the amount of work your body performs. More work generally requires more energy. More energy expenditure can naturally increase hunger.
In other words: Your appetite may be responding to your training, not the creatine itself.
Better Workouts Usually Require More Fuel
Imagine two people.
Person A
Completes:
Three light sets
Minimal effort
Leaves the gym after twenty minutes
Person B
Completes:
Progressive overload
Heavy compound lifts
More total volume
Accessory exercises
Higher weekly workload
Which athlete is more likely to be hungry afterward? Almost certainly the second. Creatine often helps people become the second athlete. That's a positive adaptation, not a negative side effect.
Does Creatine Increase Metabolism?
This is another area where nuance matters. Creatine is not a metabolic stimulant like caffeine. It doesn't suddenly accelerate metabolism after one serving.
However, creatine may indirectly support a healthier metabolism over time.
How? By helping support:
Greater training quality
Increased lean muscle mass
Better resistance-training performance
Long-term improvements in body composition
Lean muscle tissue requires energy to maintain.
Although muscle doesn't dramatically increase resting metabolic rate on its own, increasing lean mass while maintaining regular physical activity contributes to healthier long-term energy expenditure.
So the relationship looks like this: Creatine → Better Training → Potential Lean Muscle Gain → Improved Body Composition
Not: Creatine → Instant Faster Metabolism
Does Creatine Cause Cravings?
This question is different from appetite. Hunger and cravings are not the same thing.
Hunger
Hunger is your body's physiological need for energy. It develops gradually and can usually be satisfied with a balanced meal.
Cravings
Cravings are often:
Emotional
Environmental
Habit-driven
Stress-related
Triggered by highly palatable foods
Current evidence does not suggest creatine directly causes food cravings.
If you're suddenly craving:
Ice cream
Chips
Chocolate
Fast food
it's much more likely related to:
Sleep deprivation
Restrictive dieting
Stress
Food environment
Habit
rather than creatine supplementation.
Can Creatine Make Weight Loss Harder?
Not directly. One reason this myth persists is because creatine commonly increases intracellular water inside muscle cells. That extra water may increase the number you see on the scale.
People often assume, "The scale went up."
Therefore, "Creatine made me gain fat."
Those are completely different things. Body-fat gain requires a sustained calorie surplus.
Plain creatine contains essentially no nutritional calories. It cannot independently create the calorie surplus necessary for fat gain. If you're eating within an appropriate calorie deficit, creatine should not prevent fat loss.
The Ariel Hernandez Perspective
One thing I've learned as a Human Performance expert is that very few people become hungrier because of creatine itself.
What I see much more often is this, Someone begins taking creatine. They also become more consistent with training. They're lifting heavier. Walking more. Recovering better. Sleeping better. They start enjoying exercise again. Then they notice they're hungrier.
That's exactly what you'd expect from someone whose body is finally doing more work.
Instead of asking, "Did creatine increase my appetite?"
I encourage people to ask, "Am I finally giving my body a reason to ask for more fuel?"
That's a much more useful question. Because if your training quality has improved, a modest increase in appetite may actually reflect a healthier, more active lifestyle, not a problem that needs to be fixed.
10 Facts About Creatine and Appetite
Current evidence does not show that creatine directly increases appetite.
Creatine does not appear to directly alter major hunger hormones like ghrelin or leptin in healthy adults.
Better workouts may naturally increase hunger because energy expenditure increases.
Creatine is not a stimulant and does not work like caffeine.
Plain creatine contains essentially no nutritional calories.
Creatine does not directly create food cravings.
Increased scale weight after starting creatine is usually related to intracellular water, not body fat.
Creatine can support resistance training during a calorie deficit.
Appetite regulation depends on sleep, protein intake, stress, hormones, and overall energy balance, not one supplement.
Your long-term nutrition habits matter far more than whether creatine slightly changes how hungry you feel.
The Human Performance HQ F.U.E.L. Framework
One thing I have learned as a Human Performance expert is that appetite should not automatically be viewed as the enemy.
Hunger is information.
Sometimes it tells you that you have gone too long without eating. Sometimes it reflects a poorly structured diet, inadequate sleep, high stress, or an overly aggressive calorie deficit. Other times, it is simply your body's reasonable response to harder training and increased energy expenditure.
Creatine does not have an established appetite-stimulating effect. However, if it helps you train harder and more consistently, your body may legitimately need more fuel.
The Human Performance HQ F.U.E.L. Framework helps you respond to that hunger without abandoning your goals.
F — Fuel Your Performance
The first step is ensuring that your diet actually supports your workload.
If you are resistance training several days per week, walking regularly, completing conditioning sessions, or working a physically demanding job, your nutrition needs will be different from those of a sedentary person.
Prioritize meals containing:
High-quality protein
Fiber-rich carbohydrates
Fruits and vegetables
Healthy dietary fats
Adequate fluids
Creatine may support the work you perform in training, but it cannot replace the calories and nutrients required to recover from that work.
U — Understand What Kind of Hunger You Feel
Not every urge to eat represents true physiological hunger. Ask yourself whether you are experiencing:
Physical hunger?
Physical hunger usually develops gradually and may include:
An empty feeling in the stomach
Reduced energy
Difficulty concentrating
Willingness to eat several different foods
A craving
Cravings are often more specific.
You may want:
Something sweet
Something salty
A particular snack
A highly processed comfort food
Habitual eating
Sometimes people eat because:
It is a certain time of day.
They always snack while watching television.
Food is visible or easily available.
Other people are eating.
Emotional eating
Stress, boredom, loneliness, frustration, and poor sleep can all drive eating independently of physical energy needs. Creatine is not known to directly cause any of these behaviors. Recognizing the type of hunger you are experiencing helps you choose a more useful response.
E — Evaluate Your Training Load
If you recently started creatine and also changed your exercise routine, review what actually changed.
Did you begin:
Lifting heavier?
Adding more sets?
Training more frequently?
Walking more each day?
Completing harder conditioning sessions?
Recovering well enough to train consistently?
Those changes can alter appetite much more plausibly than creatine itself.
Exercise does not affect everyone’s hunger in exactly the same way. Some demanding workouts temporarily suppress appetite, while others produce greater hunger later in the day. Reviews of sports nutrition note that intense training can alter appetite patterns, and individual responses vary considerably. (SpringerLink)
L — Leverage Creatine Correctly
Creatine should be used for what it is well supported to do:
Increase muscle creatine availability
Support ATP regeneration
Improve repeated high-intensity performance
Complement resistance training
Support strength and lean-mass development
It should not be used as:
An appetite suppressant
A stimulant
A fat burner
A meal replacement
A substitute for protein
The NIH Office of Dietary Supplements describes creatine primarily as an ergogenic aid for strength, power, and repeated maximal-effort exercise, not as an appetite-regulating compound. (Office of Dietary Supplements)
Creatine During Weight Loss
Creatine can fit very well into a weight-loss program.
A productive fat-loss phase should aim to reduce body fat while preserving as much lean muscle as possible. That generally requires:
A moderate calorie deficit
Sufficient protein
Resistance training
Quality sleep
Reasonable recovery
Creatine supports the resistance-training side of that equation. It does not create the calorie deficit, but it may help you maintain training quality while eating fewer calories.
That becomes particularly useful because aggressive dieting can reduce:
Strength
Motivation
Training volume
Recovery
Exercise performance
If creatine helps you continue lifting productively, it may support better body-composition outcomes even though it does not directly control appetite.
Should You Stop Taking Creatine While Dieting?
For most healthy adults, increased hunger alone is not a compelling reason to stop taking creatine.
First evaluate more likely explanations:
Is your calorie deficit too aggressive?
Did your training volume increase?
Are you eating enough protein?
Are you sleeping poorly?
Are your meals low in fiber?
Are you confusing thirst with hunger?
Are you restricting favorite foods so heavily that cravings are increasing?
Stopping creatine may reduce some intracellular water and produce a lower number on the scale, but it does not automatically improve fat loss.
A better strategy is usually to improve the nutrition plan.
Protein Is One of Your Best Appetite-Management Tools
If appetite becomes difficult during weight loss, protein deserves attention.
Research generally shows that protein is more satiating than carbohydrate or fat. Meta-analytic evidence suggests that acute protein intake may suppress hunger, reduce ghrelin, and increase several satiety-related hormones, although long-term findings are less consistent. (PubMed)
Higher-protein diets may also support:
Lean-mass retention
Recovery
Meal satisfaction
Weight management
A practical approach is to include a meaningful protein source at each meal.
Examples include:
Chicken
Fish
Lean beef
Eggs
Greek yogurt
Cottage cheese
Tofu
Tempeh
Protein powder when useful
For active people, protein should usually receive more attention than concerns about creatine increasing appetite.
Fiber and Food Volume Matter Too
A meal can contain the correct calories and still leave you hungry if it lacks food volume, fiber, or protein.
Compare:
Lower-satiety option
Small pastry
Sweetened coffee
Minimal protein
Higher-satiety option
Eggs or Greek yogurt
Fruit
Oatmeal or whole-grain toast
Water
Both meals may fit into a calorie target, but they may affect hunger very differently.
Research on fiber and appetite is mixed because different fibers behave differently, but fruits, vegetables, legumes, and whole grains remain valuable for diet quality, food volume, and digestive health. (PubMed)
Sleep Can Affect Appetite More Than Creatine
Before blaming creatine, look at your sleep.
Poor sleep can influence:
Hunger
Cravings
Food choices
Stress
Training recovery
Impulse control
When people sleep poorly, they often crave more highly palatable, calorie-dense foods. Caffeine use can complicate this further. Someone may use caffeine to compensate for inadequate sleep, train late, sleep poorly again, and then experience stronger hunger the next day.
That cycle is far more likely to affect appetite than plain creatine monohydrate. For related guidance, read:
Hydration and Hunger Can Feel Similar
Thirst and hunger are not identical, but people can misinterpret internal signals, particularly during busy days.
If you feel suddenly hungry after training, ask:
Have I replaced the fluids I lost?
Did I sweat heavily?
Have I consumed sodium or electrolytes when appropriate?
Did I eat enough earlier in the day?
Hydration should not be used to suppress legitimate hunger.
However, addressing dehydration before reaching for random snacks can help you interpret what your body actually needs. Explore:
Creatine and Body Recomposition
Body recomposition refers to losing fat while gaining or preserving lean muscle. Creatine may support this goal by improving training capacity.
A typical body-recomposition strategy includes:
Progressive resistance training
Adequate protein
Calories matched to the goal
Consistent creatine intake
Daily movement
Sleep and recovery
Creatine may increase scale weight through intracellular water, but this does not mean body composition is worsening.
One study found that creatine increased total body water without significantly changing body-fat percentage or reported daily calorie intake. That finding does not prove creatine can never affect an individual's eating behavior, but it supports the broader point that increased scale weight and increased appetite are not automatic outcomes of supplementation. (PubMed)
Creatine Water Weight vs. Fat Gain
After starting creatine, you may gain one or more pounds. This is commonly related to water stored inside muscle cells.
Intracellular water
Occurs relatively quickly
Is stored within muscle tissue
May make muscles appear fuller
Does not require a calorie surplus
Body-fat gain
Requires sustained excess calorie intake
Accumulates over time
Is influenced by total energy balance
Is not created directly by calorie-free creatine
If the scale rises and your appetite also feels stronger, do not assume the two are proof that creatine is making you fat. Evaluate:
Weekly weight averages
Waist measurements
Training performance
Food intake
Progress photos
Clothing fit
Can Creatine Help You Stay Lean?
Creatine is not a weight-loss supplement.
However, it may indirectly support a leaner body composition by helping you:
Train harder
Preserve strength
Maintain muscle during dieting
Build lean mass over time
Stay consistent with resistance training
More lean mass does not create an enormous metabolic increase, but preserving muscle remains valuable for:
Physical function
Body composition
Healthy aging
Long-term performance
The benefit comes from the training system creatine supports, not from appetite suppression or direct fat burning.
Appetite Versus Cravings
This distinction deserves additional attention.
Appetite
Appetite is the broader desire to eat and can be influenced by physiological and environmental factors.
Hunger
Hunger is the physical need for energy.
Cravings
Cravings typically involve a strong desire for a specific food. Creatine has not been established as a trigger for cravings.
If cravings rise after starting a new training program, consider:
Excessive dietary restriction
Poor sleep
Low carbohydrate intake around training
Stress
Skipping meals
Food availability
Emotional associations with eating
Do not assume every nutrition challenge begins with the newest supplement.
Can Creatine Reduce Appetite?
Creatine should not be expected to reduce appetite either.
There is some preclinical research suggesting that brain creatine availability may interact with pathways involved in food intake, but findings from animal or laboratory models cannot be directly translated into a recommendation that creatine raises or lowers human appetite. (PubMed)
At present, the most responsible conclusion is: Creatine is not an established appetite stimulant or appetite suppressant in healthy adults.
Does Creatine Increase Daily Calorie Needs?
Creatine itself does not dramatically raise your calorie requirements.
However, the behaviors it supports might. For example, if you use creatine and begin:
Training one additional day per week
Adding several hard sets per session
Walking more
Increasing lean mass
Improving exercise consistency
your overall energy needs may rise. That increase comes primarily from your activity and body-composition changes, not from digesting creatine.
A Practical Appetite Strategy While Taking Creatine
Try the following approach:
At breakfast
Include: Protein, Fiber, and Fluids.
Before training
Eat carbohydrates and protein when needed to support performance. Fasted training is optional, not mandatory.
After training
Choose a balanced recovery meal containing:
Protein
Carbohydrates
Fruits or vegetables
Fluids and electrolytes when appropriate
During a calorie deficit
Use:
A moderate deficit
High-protein meals
High-volume foods
Consistent meal timing when helpful
Planned snacks rather than reactive grazing
When hunger changes
Track: Sleep, Training volume, Steps, Calories, Protein, and Stress. This provides far more useful information than immediately stopping creatine.
The Bigger Picture
The question “Does creatine increase appetite?” has a reassuring answer. Current evidence does not establish creatine monohydrate as an appetite stimulant.
Some people may feel hungrier after beginning creatine because they are:
Training harder
Exercising more consistently
Recovering better
Creating greater energy demands
That is an indirect relationship, not proof that creatine directly changes hunger hormones. As a Human Performance expert, I would rather help someone build meals that support their workload than remove an effective supplement based on an assumption.
Your appetite is part of a much larger system. Listen to it. Then interpret it intelligently.
FAQs
Does creatine increase appetite?
Current research does not show that creatine monohydrate directly increases appetite in healthy adults. Creatine primarily supports muscle energy metabolism and repeated high-intensity performance rather than known appetite-control pathways. Some users may feel hungrier because they begin training harder or more frequently after supplementation.
Does creatine make you hungry?
Creatine does not appear to directly create hunger, but it may indirectly contribute to increased energy needs by improving training capacity. If you complete more repetitions, lift heavier weights, or become more active, greater hunger can be a normal physiological response. Review your training volume, calorie intake, sleep, and protein before blaming creatine.
Can creatine cause food cravings?
There is no established evidence that plain creatine causes cravings for sugar, salty snacks, or highly processed foods. Cravings are more commonly influenced by stress, poor sleep, restrictive dieting, habits, and the food environment. A craving for a specific food should not automatically be interpreted as a creatine side effect.
Should I stop creatine if I am trying to lose weight?
Usually not. Creatine can support strength, productive resistance training, and lean-mass preservation during a calorie deficit. It may increase scale weight through intracellular water, but that is different from body-fat gain and does not prevent fat loss when calorie intake is appropriately controlled.
Does creatine increase metabolism?
Creatine is not a metabolic stimulant and does not rapidly increase calorie expenditure after ingestion. It may indirectly support body composition by improving training quality and helping build or preserve lean muscle. Those benefits develop through consistent training rather than an immediate metabolic boost.
Why am I hungrier after starting creatine?
You may be training harder, completing more volume, moving more, or recovering well enough to exercise more consistently. Those changes can increase energy demand and naturally increase hunger. Poor sleep, an aggressive diet, low protein, dehydration, and stress may also contribute.
Can creatine help with body recomposition?
Yes, creatine can support body recomposition when combined with resistance training and appropriate nutrition. It may improve strength and training capacity while helping support lean muscle development or preservation. It does not directly burn fat, so calorie intake and overall activity still determine whether body-fat loss occurs.
Key Takeaways
Current evidence does not establish creatine as a direct appetite stimulant.
Harder training after starting creatine may indirectly increase hunger.
Creatine is not known to directly cause food cravings.
Protein, fiber, sleep, hydration, stress, and calorie intake have much larger effects on appetite.
Creatine can support strength and lean-mass retention during weight loss.
Initial scale weight gain is often intracellular water, not fat.
Evaluate your complete training and nutrition system before removing creatine.
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RESEARCH BACKED CITATIONS
NIH Office of Dietary Supplements. Dietary Supplements for Exercise and Athletic Performance. Provides evidence-based information on creatine’s effects on strength, power, repeated high-intensity exercise, dosing, and safety.https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/
Kutz MR, Gunter MJ. Creatine Monohydrate Supplementation on Body Weight and Percentage of Body Fat. This study found increased total body water without significant changes in percent body fat or reported daily calorie intake. https://pubmed.ncbi.nlm.nih.gov/14636103/
Antonio J, Candow DG, Forbes SC, et al. Common Questions and Misconceptions About Creatine Supplementation. A peer-reviewed review addressing creatine safety, water retention, body composition, dosing, and common misconceptions. https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00412-w
Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine.A comprehensive position stand reviewing creatine performance benefits, safety, and clinical applications. https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z
Kohanmoo A, Faghih S, Akhlaghi M. Effect of Short- and Long-Term Protein Consumption on Appetite and Appetite-Regulating Gastrointestinal Hormones.This meta-analysis found that acute protein consumption may suppress appetite, reduce ghrelin, and increase several satiety-related hormones. https://pubmed.ncbi.nlm.nih.gov/32768415/
Paddon-Jones D, Westman E, Mattes RD, et al. Protein, Weight Management, and Satiety.Reviews evidence that protein is generally more satiating than carbohydrate or fat and may support body-weight management. https://pubmed.ncbi.nlm.nih.gov/18469287/
Leidy HJ, Clifton PM, Astrup A, et al. The Role of Protein in Weight Loss and Maintenance.Reviews protein’s effects on appetite, satiety, lean-mass preservation, and weight management. https://pubmed.ncbi.nlm.nih.gov/25926512/
Klok MD, Jakobsdottir S, Drent ML. The Role of Leptin and Ghrelin in the Regulation of Food Intake and Body Weight in Humans. Explains the roles of leptin and ghrelin in appetite, energy balance, and body-weight regulation. https://pubmed.ncbi.nlm.nih.gov/17212793/
Clark MJ, Slavin JL. The Effect of Fiber on Satiety and Food Intake: A Systematic Review.Examines how different fiber types and doses affect appetite and subsequent food intake.https://pubmed.ncbi.nlm.nih.gov/23885994/
Kerksick CM, Wilborn CD, Roberts MD, et al. ISSN Exercise and Sports Nutrition Review Update: Research and Recommendations. Discusses sports nutrition, training demands, appetite changes, recovery, and evidence-based supplementation. https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0242-y
Galbraith RA, Furukawa M, Li M. Possible Role of Creatine Concentrations in the Brain in Regulating Appetite and Weight. A preclinical study suggesting a possible relationship between brain creatine availability and food intake; it should not be interpreted as evidence that oral creatine increases appetite in humans. https://pubmed.ncbi.nlm.nih.gov/16781683/
